Screenshots1 / 2
Dr. Mario 64
马里奥：Dr. 64
Dr. Mario 64, developed by Newcom in 2001, is a puzzle-action game for Nintendo 64. Players drop and rotate colored pills into a glass container to match viruses of the same color, creating four-in-a-row eliminations. The game offers multiple gameplay modes, including a story campaign that progresses through stages with increasing difficulty and opponent variety. The N64 controller uses the D-pad to move pills left or right, and button inputs rotate pieces before they fall. Supporting up to four players, the game includes competitive modes where players battle each other simultaneously and cooperative modes for shared gameplay. The single-player campaign features progressive difficulty scaling, with each stage introducing distinct challenges and new virus patterns.
- Developer
- Newcom
- Released
- 2001
- Platform
- N64
- Genre
- Action
- Players
- 4P
- Rating
- 4.6 / 5 (6.4K)
- Last updated
Dr. Mario 64 Controls — N64 Keyboard Keys
Default keyboard bindings for Dr. Mario 64 on our in-browser N64 emulator. Plug in a USB or Bluetooth gamepad to auto-detect mappings, or rebind any key from the emulator settings menu.
| Keyboard | Console button | Typical use |
|---|---|---|
| ↑ | D-Pad Up | Move up |
| ↓ | D-Pad Down | Move down |
| ← | D-Pad Left | Move left |
| → | D-Pad Right | Move right |
| X | A | Primary action (jump / confirm) |
| Z | B | Secondary action (attack / cancel) |
| V | Z (trigger) | Z trigger (back) |
| Q | L | Left shoulder |
| W | R | Right shoulder |
| I | C-Up | C-Up (camera up) |
| K | C-Down | C-Down (camera down) |
| J | C-Left | C-Left (camera left) |
| L | C-Right | C-Right (camera right) |
| Enter | Start | Start / Pause |
The N64 thumbstick is mapped to the arrow keys by default; many titles also let you remap it from the in-game options screen. The Z trigger is mapped to V.
Rebind any key from the EmulatorJS in-game settings menu (gear icon → Controls). A connected gamepad auto-maps to the same buttons.
Dr. Mario 64 Longplay & Gameplay Videos
Watch a full playthrough of Dr. Mario 64 on N64 before you dive in — recommended for getting a feel for the game's pacing, story beats, and difficulty curve.
Watch longplay on YouTube
"Dr. Mario 64" N64 longplay 2001
Dr. Mario 64 Cheat Codes
30 community-curated cheats for Dr. Mario 64. Tick any to activate them automatically when you click "Play with cheats" — or copy a code into your own emulator.
-
Enable Code (M)
F100D2E02400 -
P1 Dual Activator
D101D8040000 -
P1 Activator 1
D001D8040000 -
P1 Activator 2
D001D8050000 -
P2 Dual Activator
D101D80C0000 -
P2 Activator 1
D001D80C0000 -
P2 Activator 2
D001D80D0000 -
P3 Dual Activator
D101D8140000 -
P3 Activator 1
D001D8140000 -
P3 Activator 2
D001D8150000 -
P4 Dual Activator
D101D81C0000 -
P4 Activator 1
D001D81C0000
Show 18 more cheats Show fewer
-
P4 Activator 2
D001D81D0000 -
Activator 1 P1 #2
D00EB4D80000 -
Activator 2 P1 #2
D00EB4D90000 -
Activator 1 P2 #2
D00EB4DE0000 -
Activator 2 P2 #2
D00EB4DF0000 -
Activator 1 P3 #2
D00EB4E40000 -
Activator 2 P3 #2
D00EB4E50000 -
Activator 1 P4 #2
D00EB4EA0000 -
Activator 2 P4 #2
D00EB4EB0000 -
Dual Activator P1 #2
D10EBCF80000 -
Dual Activator P2 #2
D10EBCFA0000 -
Dual Activator P3 #2
D10EBCFC0000 -
Dual Activator P4 #2
D10EBCFE0000 -
Dual Activator P1 #3
D10F3E640000 -
Dual Activator P2 #3
D10F4E660000 -
Dual Activator P3 #3
D10F3E680000 -
Dual Activator P4 #3
D10F3E6A0000 -
Number of Games Per Match
8008841B0001
External references
Frequently Asked Questions
When was Dr. Mario 64 released?
Dr. Mario 64 was released in 2001 for the N64.
Who developed Dr. Mario 64?
Dr. Mario 64 was developed by Newcom, available to play in your browser on RetroGameSpace.
How many players does Dr. Mario 64 support?
Dr. Mario 64 supports up to 4 players, ideal for couch co-op or competitive sessions on the N64.
What type of game is Dr. Mario 64?
Dr. Mario 64 is a Action game for the N64, playable instantly in your browser — no downloads, no installs.
How can I play Dr. Mario 64 for free?
Open this page and click "Play Now" — Dr. Mario 64 runs free in your browser via WebAssembly emulation. No account, no payment, no installer.
Do I need to download anything to play Dr. Mario 64 in the browser?
No. Dr. Mario 64 streams from a public archive into a browser-side N64 emulator. Nothing is installed on your computer.
Can I save my progress in Dr. Mario 64?
Yes. Save states are stored in your browser (IndexedDB) per game, and you can also use any in-game save the original N64 cartridge supported.
Does Dr. Mario 64 work on mobile devices?
Yes — the N64 emulator runs on iOS Safari and Android Chrome. Touch controls overlay the game; landscape mode is recommended.
Is it legal to play Dr. Mario 64 this way?
RetroGameSpace is a transient caching reverse-proxy and does not host first-party copies of Dr. Mario 64. Game files are fetched on demand from publicly-accessible archives. You are responsible for compliance with your local laws and the bring-your-own-ROM principle.
